In Once Human, your choice of gear and weapons is crucial to dominating in combat. Whether you're facing off against corrupted beasts in PvE zones or launching raids on player settlements in PvP, a well-optimized build can mean the difference between victory and defeat.
This guide delves into four of the most potent builds currently available in Once Human, offering in-depth information on weapons, gear modifications, synergy effects, and strategic playstyle tips. From area-of-effect (AoE) builds designed for efficient clearing to damage-over-time (DoT) and critical burst setups, each loadout has been rigorously tested for both solo and team play scenarios.
If you're just starting out, make sure to explore our Beginner’s Guide for Once Human to get a thorough introduction to the game!

Final Tips for Optimizing Your Build
- Sync Weapon Effects and Mods: Select gear that amplifies your weapon’s elemental or status effects for maximum impact.
- Keep Upgrading: Higher rarity and enhancement levels significantly enhance your build’s effectiveness—always stay up-to-date with your gear.
- Craft Backup Loadouts: Preparing a secondary build focused on different elements can help you adapt to various mutant types or counter PvP strategies effectively.
Each build in Once Human is tailored for specific scenarios, be it tackling boss fights, clearing waves, or executing swift PvP takedowns. It's essential to experiment with different loadouts, refine your gear mods, and switch between builds based on the mission type or enemy resistances you're facing.
For an optimal gaming experience—featuring lag-free aiming, the ability to farm across multiple instances, and swift inventory management—consider playing Once Human on BlueStacks. Enhance your gameplay with complete control support and enjoy ultra-smooth frame rates.